Cigarettes and the wages of sn-2: oxidized species of PAF in smoking hamsters.
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چکیده
منابع مشابه
Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation.
Oxidation of LDL is thought to be involved in both initiating and sustaining atherogenesis through the formation of proinflammatory lipids and the covalent modification of LDL particles. Platelet-activating factor (PAF; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent phospholipid mediator involved in inflammation. Upon oxidation of LDL, oxidized phospholipids with PAF-like structure...
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Smoking and cigarettes permanent consumption caused by common misbelieve in society. The aim of this study is that what are the effects of smoking on the tendency of people to drug abuse? "Gateway hypothesis" is one of the theories about addiction and drug use. According to this hypothesis, the use of drugs, is started with legal drug abuse and is developed to "hard drug". Review of the documen...
متن کاملDetermination of phospholipase activity of PAF acetylhydrolase.
This article presents a radiometric assay to determine the enzymatic activity of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 and phospholipase A2 group 7A. The method is based on the release of radioactively labeled acetate from sn-2-labeled PAF and separation of substrate and product using reversed-phase column chromatography...
متن کاملPlatelet-activating factor and oxidized phosphatidylcholines do not suppress endotoxin-induced pro-inflammatory signaling among human myeloid and endothelial cells
Platelet-activating factor (PAF) and related phospholipid oxidation products termed oxidized phospholipids (OxPLs) promote inflammation. PAF is made in response to bacterial endotoxin-lipopolysaccharide (LPS) that is recognized by Toll-like receptor-4 (TLR-4) whose activation leads to translocation of transcription factor NF-ΚB to the nucleus—a key regulator of multiple pro-inflammatory genes i...
متن کاملRegulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase.
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 99 10 شماره
صفحات -
تاریخ انتشار 1997